Atorvastatin is a statin (HMG‑CoA reductase inhibitor) used widely across Europe to reduce elevated cholesterol and lower the risk of cardiovascular disease. By inhibiting hepatic HMG‑CoA reductase, atorvastatin decreases endogenous cholesterol synthesis and up‑regulates LDL receptors on hepatocytes. The result is enhanced clearance of circulating low‑density lipoprotein cholesterol (LDL‑C) and apolipoprotein B–containing particles, a modest rise in high‑density lipoprotein cholesterol (HDL‑C), and reductions in triglycerides and non‑HDL cholesterol.
Extensive outcome trials have shown that statin therapy, including atorvastatin, reduces myocardial infarction, ischaemic stroke, coronary revascularisation, and cardiovascular mortality when used long‑term in appropriate patients. Atorvastatin is considered a potent statin; treatment goals are individualised using absolute risk and lipid‑lowering targets outlined by European guidelines. Alongside medication, lifestyle measures—heart‑healthy diet, regular physical activity, weight management, smoking cessation, and blood pressure/diabetes control—remain essential to maximise risk reduction.
Atorvastatin is taken once daily, with or without food, at any time of day. Lipid panels are typically checked 4–12 weeks after initiation or dose change, and periodically thereafter, to assess adherence and LDL‑C response. The drug is generally well tolerated; most people experience no side effects. Muscle symptoms and abnormal liver tests are uncommon and usually manageable with clinical review and dose adjustment or switching where needed.
Atorvastatin is licensed in the EU for adults, adolescents, and children ≥10 years (age ranges may vary by brand) for the management of dyslipidaemia and prevention of cardiovascular events as part of a comprehensive risk‑reduction plan.
If chest pain, sudden weakness/numbness, speech difficulty, or severe breathlessness occur, seek urgent medical help—these symptoms require immediate evaluation and are not treated by statins.
Most people tolerate atorvastatin well. Side effects, when they occur, are often mild and transient. Serious adverse effects are uncommon but require prompt attention.
Many muscle symptoms have alternative explanations (exercise, thyroid dysfunction, vitamin D deficiency, interacting drugs). Do not discontinue without medical advice; clinicians can evaluate causes and consider re‑challenge, dose reduction, or switching statins.
Share your full medical history, including prior statin intolerance, endocrine disorders, and kidney problems. Targets and dosing are individualised to your absolute cardiovascular risk and guideline goals.
Atorvastatin is metabolised primarily by CYP3A4 and transported by OATP1B1/1B3. Some medicines increase its blood levels (raising muscle‑related risk), while others reduce its effectiveness. Always provide your clinician and pharmacist with a complete list of medicines and supplements.
Herbals/supplements: Red yeast rice contains statin‑like compounds and can duplicate effects; avoid. Discuss high‑dose niacin or other lipid‑active supplements with your clinician.
Missed dose: Take it when remembered unless it is close to the next scheduled dose. If so, skip the missed tablet and resume the regular schedule. Do not take two doses together.
Accidental double dose: Usually low risk; you may notice stomach upset or muscle aches. Do not take extra doses to catch up. If you develop persistent muscle pain/weakness or dark urine, contact your clinician.
Large overdose: There is no specific antidote. Seek medical assessment. Hospital care is supportive, with monitoring of liver function, CK, renal function, and hydration.
Always read the patient leaflet and follow your prescriber’s instructions. If you have questions about dosing or side effects, consult your pharmacist or clinician.
The information provided on this website is for general educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your doctor, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Do not disregard professional medical advice or delay seeking it because of something you have read here. We do not take responsibility for any loss, damage, or injury caused by this information.